I'm not sure. I suppose I'd have to go with a tie between the original Pac-Man and Asteroids, with Space Invaders running a close third. That's just me, though.
I think the best game of all time would be either Defender, Missile Command, or Asteroids.
I think Ms. Pacman has some explaining to do...she lives with Pacman and has a baby (Pacman, Jr.), but she's obviously not married to him or else she'd be Mrs. Pacman.